血吸虫对宿主初级凝血、次级凝血、血管内皮功能存在干扰作用,对纤维蛋白溶解存在刺激活化作用,说明血吸虫的寄生伴随着复杂的抗凝血机制。本文介绍了国内外有关血吸虫抗宿主凝血机制研究方面的进展,为血吸虫抗体药物及新型生物学抗血栓药物或溶栓药物的研究提供理论依据。 Schistosoma japonicum on the host primary coagulation, secondary coagulation, vascular endothelial dysfunction, there is stimulation of fibrinolytic activation, indicating that schistosome parasites accompanied by complex anticoagulant mechanism. This article introduces the research progress of schistosomal anti-host coagulation mechanism at home and abroad, and provides a theoretical basis for the study of schistosome antibody drugs and new biological antithrombotic drugs or thrombolytic drugs.