可卡因对胎鼠脑细胞DNA含量的影响

来源 :中国神经精神疾病杂志 | 被引量 : 0次 | 上传用户：chnlaozhang

【摘要】

：

目的探讨不同剂量可卡因对胎鼠脑细胞DNA含量的影响.方法实验组每日分别给妊娠Wistar大鼠皮下注射不同剂量的盐酸可卡因15天.对照组每日给相同剂量的普通生理盐水15天.在可卡

【作者】

：

吴岚莹刘剑新王华沈朝斌孙金平顾君夏良斌夏尤佳于朝春

【机构】

：

上海市中西医结合医院儿科,上海,200082;上海市中西医结合医院泌尿外科,上海,200082;上海市中西医结合医院神经外科,上海,200082

【出处】

：

中国神经精神疾病杂志

【发表日期】

：

2004年2期

【关键词】

：

可卡因脑细胞凋亡 DNA

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

目的探讨不同剂量可卡因对胎鼠脑细胞DNA含量的影响.方法实验组每日分别给妊娠Wistar大鼠皮下注射不同剂量的盐酸可卡因15天.对照组每日给相同剂量的普通生理盐水15天.在可卡因使用的第15天分别取胎鼠大脑组织.用流式细胞技术检测脑细胞DNA含量及细胞凋亡.结果在使用可卡因15 mg/kg和25mg/kg组出现脑细胞凋亡,且脑细胞DNA含量减少,与对照组比较有显著性差异(P＜0.05),而1.5mg/kg组未出现脑细胞凋亡.结论使用大剂量可卡因可以诱导胎鼠脑细胞凋亡,导致胎鼠脑细胞DNA含量减少.

其他文献

Schwann cell Myc-interacting zinc-finger protein 1 without pox virus and zinc finger: epigenetic imp

Functionality of adult peripheral nerves essentially relies on differentiation of Schwann cells during postnatal development,as well as fine-tuned re-and transd

期刊

Schwann celldifferentiationperipheral nerve injuryhistone methylationepigene

Promoting axonal regeneration following nerve surgery: a perspective on ultrasound treatment for ner

Nerve injury is often associated with limited axonal regeneration and thus leads to delayed or incomplete axonal reinnervation.As a consequence of slow nerve re

期刊

peripheral nerve injuriesnerve regenerationreinnervationexperimental studies

Real world studies are essential for drug therapy in Parkinson's disease

期刊

The emerging epigenetics of PARK7 and its implication in neurodegenerative disease

期刊

Regulation of neural stem cell fate decisions by mitochondrial dynamics

Stem cells possess the ability to divide symmetrically or asymmetrically to allow for maintenance of the stem cell pool or become committed progenitors and diff

期刊

A radical scavenger edaravone and oligodendrocyte protection/ regeneration

Cerebral white matter is vulnerable to oxidative stress:Oxidative stress is one of the major harmful conditions for the central nervous system (CNS).Oxidative s

期刊

3'-Daidzein sulfonate sodium protects against memory impairment and hippocampal damage caused b

期刊

Mitochondrial division inhibitor 1 protects cortical neurons from excitotoxicity: a mechanistic path

Mitochondrial division inhibitor 1 (Mdivi-1) is a selective cell-permeable inhibitor of dynamin-related protein-1 (Drp 1) and mitochondrial division.To investig

期刊

nerve regenerationmitochondrial division inhibitor 1neuronsapoptosismitochon

Limb remote ischemic postconditioning protects integrity of the blood-brain barrier after stroke

期刊

nerve regenerationremote ischemic postconditioningmiddle cerebral artery occlu

Electroacupuncture exerts neuroprotective effects on ischemia/reperfusion injury in JNK knockout mic

期刊

nerve regenerationMAPKs signaling pathwaycerebral ischemia/reperfusionstress-

可卡因对胎鼠脑细胞DNA含量的影响

与本文相关的学术论文