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目的:研究治疗肺间质纤维化新药吡非尼酮导致皮肤光敏反应这一特殊不良反应的一般规律,为临床安全合理用药提供参考依据。方法:采用文献回顾性研究的方法,对吡非尼酮导致光敏反应患者的临床资料进行统计分析。结果:吡非尼酮导致患者光敏反应是一种光毒性反应,不良反应发生可能与生活方式、用药剂量有关,出现光敏反应建议暂停药物治疗,对症处理。结论:临床应用吡非尼酮应加强预防与用药监测,以避免和减少光敏反应的发生。
OBJECTIVE: To study the general rules of treating the special adverse reaction caused by pirfenidone, a new drug for pulmonary interstitial fibrosis, to provide a reference for the safe and rational drug administration. Methods: The retrospective study of the literature, the pirfenidone lead to photosensitive reaction in patients with clinical data for statistical analysis. Results: Phenylphenidone led to the patient’s photosensitive reaction is a phototoxic reaction, adverse reactions may be related to lifestyle, dosage, the emergence of photosensitive reaction is proposed to suspend drug treatment, symptomatic treatment. Conclusion: The clinical application of pirfenidone should strengthen the prevention and medication monitoring in order to avoid and reduce the occurrence of photosensitive reaction.