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目的探讨左乙拉西坦联合丙戊酸钠治疗癫持续性状态患者的临床疗效。方法选取2013年1月至2015年5月辽宁省葫芦岛市中心医院神经内科收治的54例癫持续状态患者作为研究对象,采用随机数字表法将其分为对照组与观察组,各27例。对照组患者给予左乙拉西坦,观察组患者在对照组基础上采用丙戊酸钠注射液进行治疗,比较两组患者的治疗效果、不良反应发生情况、复发情况及癫控制时间。结果观察组患者治疗的总有效率明显高于对照组,差异有统计学意义(P<0.05);观察组患者的不良反应发生率明显低于对照组,差异有统计学意义(P<0.05);治疗后,观察组患者的复发率明显低于对照组,差异有统计学意义(P<0.05);观察组患者癫控制时间为(40±6)min,明显短于对照组的(49±3)min,差异有统计学意义(P<0.05)。结论对癫持续状态患者采用左乙拉西坦联合丙戊酸钠注射液进行治疗,临床疗效明显,可有效控制患者癫持续状态,且安全性高,不良反应少。
Objective To investigate the clinical efficacy of levetiracetam combined with sodium valproate in the treatment of persistent epileptic patients. Methods From January 2013 to May 2015, 54 patients with status epilepticus admitted to Department of Neurology, Huludao Central Hospital of Liaoning Province were enrolled in this study. They were divided into control group and observation group by random number table example. Patients in the control group were treated with levetiracetam. The patients in the observation group were treated with sodium valproate on the basis of the control group. The treatment effect, adverse reactions, recurrence and epilepsy control time were compared between the two groups. Results The total effective rate of observation group was significantly higher than that of control group (P <0.05). The incidence of adverse reactions in observation group was significantly lower than that of control group (P <0.05) ; After treatment, the recurrence rate of the observation group was significantly lower than that of the control group, the difference was statistically significant (P <0.05); the observation group patients with epilepsy control time (40 ± 6) min, significantly shorter than the control group (49 ± 3) min, the difference was statistically significant (P <0.05). Conclusions The treatment of patients with status epilepticus by levetiracetam combined with sodium valproate injection has obvious curative effect and can effectively control the status of epilepsy in patients with high safety and few adverse reactions.