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给家兔灌服甲苯咪唑 β- CD包合物胶囊 (40 mg/kg)和安乐士片剂 (40 mg/kg) ,用反相高效液相色谱法测定兔血药浓度。结果表明 :β- CD包合物比片剂在兔体内达峰浓度早 ,峰浓度值高 ,相对生物利用度为 52 8%。
The rabbits were orally given the omeprazole β-CD inclusion complex capsules (40 mg / kg) and Ehrlich tablets (40 mg / kg), and the rabbit plasma concentrations were determined by RP-HPLC. The results showed that the relative bioavailability of β-CD inclusion complex was 52.8% higher than that of the tablet in rabbits.