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近年的研究提示，卵巢早衰与免疫紊乱有关。本研究用流式细胞仪分拣细胞，结合原位杂交的方法研究卵巢早衰患者外周血ＣＤ４＋Ｔ淋巴细胞Ｔｈ１／Ｔｈ２分布，旨在探讨卵巢早衰自身免疫损伤的机制。结果：卵巢早衰组Ｔｈ１细胞百分比（４９７６±９２２）明显高于对照组（２００６±７１０）（Ｐ＜０．００１）；Ｔｈ１／Ｔｈ２细胞比值（１１５±０１７）明显高于对照组（０６３±００９）（Ｐ＜０．００１）。提示Ｔｈ１，Ｔｈ２细胞调节失衡，可能与卵巢早衰的发生有关。
Recent studies suggest that premature ovarian failure and immune disorders. In this study, we used flow cytometry to classify cells and study the distribution of Th1 / Th2 in peripheral blood CD4 + T lymphocytes in patients with premature ovarian failure by in situ hybridization to investigate the mechanism of autoimmune damage in premature ovarian failure. Results: The percentage of Th1 cells in premature ovarian failure group (4976 ± 922) was significantly higher than that in control group (2006 ± 710) (P0.001). Th1 / Th2 cell ratio (115 ± 0 17) was significantly higher than the control group (063 ± 009) (P <0.001). Tip Th1, Th2 cells regulate imbalance may be related to the occurrence of premature ovarian failure.