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目的观察干扰素外用与干扰素皮损内注射治疗女性生殖道尖锐湿疣(CA)的疗效与不良反应。方法将96例女性生殖道CA患者随机分为两组,干扰素外用组(48例)采用重组人干扰素α-2b阴道泡腾片配合高频电刀治疗,干扰素病灶内注射组(48例)采用重组干扰素α-2b皮损内注射配合高频电刀治疗。结果两组治愈率、复发率比较,差异无统计学意义(P>0.05);两组人乳头瘤病毒(HPV)转阴率、不良反应率比较差异有统计学意义(P<0.05)。结论干扰素栓阴道给药,不良反应小,治愈率高,复发率低,能有效地减少HPV病毒负荷量,疗效肯定。
Objective To observe the efficacy and side effects of interferon external use and interferon injection in the treatment of female reproductive tract condyloma acuminatum (CA). Methods Ninety-six female genital tract CA patients were randomly divided into two groups. Interferon external use group (48 cases) was treated with recombinant human interferon α-2b vaginal effervescent tablets with high-frequency electric knife, and interferon intralesional injection group Example) The use of recombinant interferon alpha-2b skin lesions with high frequency electrosurgical injection. Results There was no significant difference in the cure rate and recurrence rate between the two groups (P> 0.05). There was significant difference between the two groups in the rate of negative conversion and the rate of adverse reactions (P <0.05). Conclusions Interferon suppository vaginal administration, small adverse reactions, high cure rate, low recurrence rate, can effectively reduce the load of HPV virus, the effect is sure.