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目的探讨非瓣膜病房颤(NVAF)患者发生缺血性脑卒中(IS)的危险因素。方法回顾分析我院住院的NVAF患者相关临床资料,分析其IS发生的高危因素。结果 481例NVAF患者IS发生率14.55%,华法林使用率23.07%,INR达标率6.44%。多因素Logistic回归模型分析显示:高龄(OR=3.003,p=0.003)、高血压(OR=1.953,p=0.016)、糖尿病(OR=2.153,p=0.007)、左心室收缩功能减退(OR=2.201,p=0.005)、左房增大(OR=2.128,p=0.007)、持续性房颤(OR=2.309,p=0.014)是IS发生的高危因素。结论 NVAF合并高龄、高血压、糖尿病、左房增大、左心室收缩功能减退、持续性房颤增加IS的发生率。本地区INR达标率极低。
Objective To investigate the risk factors of ischemic stroke (IS) in patients with nonvalvular atrial fibrillation (NVAF). Methods The clinical data of NVAF patients hospitalized in our hospital were retrospectively analyzed, and the risk factors of IS were analyzed. Results 481 NVAF patients with IS incidence of 14.55%, warfarin usage rate of 23.07%, INR compliance rate of 6.44%. Multivariate logistic regression analysis showed that in elderly (OR = 3.003, p = 0.003), hypertension (OR = 1.953, p = 0.016), diabetes (OR = 2.153, p = 0.007), left ventricular systolic dysfunction (OR = 2.201, p = 0.005). Left atrial enlargement (OR = 2.128, p = 0.007) and persistent AF (OR = 2.309, p = 0.014) were risk factors for IS. Conclusions NVAF complicated with senile hypertension, diabetes mellitus, left atrium enlargement, left ventricular systolic dysfunction and persistent atrial fibrillation increased the incidence of IS. INR is very low in the region.