Ｇｒａｖｅ′ｓ 眼病（ＧＯ）被认为是与Ｇｒａｖｅ′ｓ甲亢密切相关的一种自身免疫性疾病，其发病率较高。近年来，关于外科治疗、内科治疗、１３１　Ｉ治疗等三种方法治疗甲亢是否会引起Ｇｒａｖｅ′ｓ 病（ＧＤ）加重的问题受到广泛重视。许多回顾性的研究未发现三种方法治疗后引起ＧＤ加重的几率有显著性差异，但一些前瞻性的研究表明，１３１　Ｉ治疗会引起眼病加重，其原因可能是１３１　Ｉ治疗后发生甲低及促甲状腺素（ＴＳＨ）受体的抗体水平增加。 Grave’s eye disease (GO) is considered as an autoimmune disease that is closely related to Grave’s hyperthyroidism and has a high incidence. In recent years, the problems of whether the treatment of hyperthyroidism caused Grave’s disease (GD) by the three methods of surgical treatment, internal medicine treatment and 131 I treatment are widely valued. Many retrospective studies have found no significant difference in the odds of having the disease aggravated by the three treatments, but some prospective studies have shown that 131 I treatment causes eye disease exacerbations, possibly due to hypothyroidism after 131 I treatment and Anti-thyroid hormone (TSH) receptor antibody levels increase.