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一、緒言甘油栓在許多国家的药典中均被收載;但其制备方法各有所不同,有的是直接用硬脂酸鈉与甘油作原料;有的是用硬脂酸与碳酸鈉或氢氧化鈉(或碳酸氢鈉)皂化后生成硬脂酸鈉与甘油作原料;有的是用明膠加甘油制备。总的說来有兩种制备方法,一是硬脂酸鈉的肥皂加甘油,另一是明膠加甘油。按各药典的方法,制备的制品均不理想(見后表),主要是“出汗”严重;在室温貯存后容易变形;并且在体内不易熔化。經过一系列的摸索,改变了处方內容,基本上已克服了“出汗”現象,並在37℃經30—40分钟后能全部熔化,初步得到了較为滿意的制品。
I. INTRODUCTION Glycerol suppositories have been included in the pharmacopoeias of many countries; however, their preparation methods are different. Some of them use sodium stearate and glycerin as raw materials; some use stearic acid and sodium carbonate or sodium hydroxide ( Or saponification of sodium bicarbonate) produces sodium stearate and glycerine as raw materials; some are prepared with gelatin and glycerol. In general, there are two methods of preparation, one is sodium stearate soap plus glycerol, and the other is gelatin plus glycerin. According to the methods of each pharmacopoeia, the prepared products are not ideal (see the table below), mainly “sweating”; they are easily deformed after storage at room temperature; and they are not easily melted in the body. After a series of explorations, the content of prescriptions was changed, and the “sweating” phenomenon was basically overcome. After melting at 37° C. for 30 to 40 minutes, it was completely melted, and preliminary satisfactory products were obtained.