患者,女性,44岁,主因全身红斑伴瘙痒9个月入院。患者于1989年起首先出现背部皮肤红斑,瘙痒。外院以过敏性皮炎治疗无效。红斑渐扩及全身,部分形成肿块。小者直径约1cm,大者约20cm。再次以结核性结节红斑治疗无效,肿块破溃。于1998年8月入我科。体检:一般状况好,全身皮肤散在暗红色红斑,右膝关节处可见直径约20cm肿块,中心隆起、破溃。右背部可见22个约2.0cm×2.0cm大小的红色肿块。浅表淋巴结未触及肿大。心肺无异常,腹平软、无压痛,肝脾肋下未及,腹水征阴性,双下肢无水肿。入院后行肿块活检,病理报告:真皮中 Patients, female, 44 years old, mainly due to systemic erythema with itching 9 months admission. Patients first appeared back skin erythema in 1989, itching. Outside the hospital to allergic dermatitis treatment is invalid. Erythema gradually spread and the body, part of the formation of lumps. Small diameter of about 1cm, the largest about 20cm. Once again to tuberculous nodules erythema treatment ineffective, ulcerated tumor. In 1998 August into my department. Physical examination: the general condition is good, the whole body scattered in the dark red skin erythema, right knee can be seen at a diameter of about 20cm mass, central uplift, ulceration. Right back visible 22 about 2.0cm × 2.0cm size of the red mass. Superficial lymph nodes did not touch swollen. No abnormal heart and lung, abdominal soft, no tenderness, liver and spleen ribs, ascites sign negative, no lower extremity edema. After admission, mass biopsy, pathology report: dermis