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目的分析抗SmD1抗体检测在系统性红斑狼疮(SLE)中的应用价值。方法检测143例SLE患者和105例非SLE患者的抗SmD1抗体(酶联免疫吸附试验)、抗ds DNA抗体(间接免疫荧光法)、Anu A和抗Sm抗体(殴蒙斑点法),分析抗SmD1抗体在SLE诊断中的价值、与患者疾病活动性的关系及抗SmD1抗体阳性SLE患者的临床特征。结果抗SmD1抗体在SLE诊断中的敏感性为68.53%,特异性为97.14%,敏感性明显高于其他自身抗体,差异有统计学意义(P<0.05),而诊断特异性比较,差异无统计学意义(P>0.05);抗SmD1抗体与SLE患者疾病活动性呈正相关(r=0.689,P=0.027);抗SmD1抗体阳性的SLE患者发热、关节炎、狼疮肾炎、血液系统异常及雷诺现象的发生率明显高于阴性组,差异有统计学意义(P<0.05)。结论抗SmD1抗体检测在SLE患者的诊断及疾病进程具有重要的参考价值。
Objective To analyze the value of anti-SmD1 antibody detection in systemic lupus erythematosus (SLE). Methods The anti-SmD1 antibody, anti-ds DNA antibody (indirect immunofluorescence assay), Anu A and anti-Sm antibody (anti-Sm antibody) were detected in 143 SLE patients and 105 non-SLE patients. The value of SmD1 antibody in the diagnosis of SLE, the relationship with disease activity and the clinical features of anti-SmD1 antibody positive patients with SLE. Results The sensitivity of anti-SmD1 antibody in SLE diagnosis was 68.53%, specificity was 97.14%, the sensitivity was significantly higher than other autoantibodies, the difference was statistically significant (P <0.05), but the diagnostic specificity was not statistically different (R = 0.689, P = 0.027). Anti-SmD1 antibody-positive patients with SLE had fever, arthritis, lupus nephritis, hematologic abnormalities and Raynaud’s phenomenon The incidence was significantly higher than the negative group, the difference was statistically significant (P <0.05). Conclusion The detection of anti-SmD1 antibody has important reference value in the diagnosis and disease progression of SLE patients.