用对阿霉素较为敏感的艾氏腹水癌在小鼠体内用阿霉素进行长达50 wk的治疗,致使EAC细胞对阿霉素产生抗药性.抗药性细胞的生长比敏感株缓慢,每只小鼠体内总的瘤细胞体积,细胞计数,及平均单一细胞体积均比敏感株明显为小,同时还发现染色体匀染及双微体结构.该模型对长春新碱,放线菌素D.及丝裂霉素C均产生交叉抗药性,对VP-16产生部分交叉抗药性.而对冬凌草甲素则无交叉抗药性. Ehrlich ascites carcinoma, which is more sensitive to doxorubicin, was treated with doxorubicin for up to 50 weeks in mice, resulting in resistance to doxorubicin in EAC cells.The growth of drug-resistant cells was slower than that of the sensitive strains The total volume of tumor cells, cell count and the average single cell volume in mice were significantly smaller than those in the sensitive strains, meanwhile, the chromosomal homogenization and double micro-structure were also found in this model.Vincristin, actinomycin D And mitomycin C were cross-resistance, cross-resistance to VP-16 produced a partial cross-resistance to oridonin cross-resistance.