论文部分内容阅读
目的观察阿霉素神经阻滞治疗原发性三叉神经痛的临床效果。方法选择2008年4月至2011年3月濮阳市油田总医院口腔科收治的原发性三叉神经痛患者175例(209支),随机分为阿霉素组(87例,104支)和无水乙醇组(88例,105支)。阿霉素组用1%阿霉素神经阻滞,无水乙醇组用无水乙醇神经阻滞,观察治疗后7d临床疗效及局部反应,并随访2年。结果治疗后7d并发症比较,阿霉素组局部肿胀9支、疼痛10支、神经分布区域麻木26支;无水乙醇组局部肿胀19支、疼痛20支、神经分布区域麻木36支,组间比较差异有统计学意义(P<0.05)。临床疗效比较,治疗后7d阿霉素组有效率为93%,与无水乙醇组(91%)比较差异无统计学意义(P>0.05);治疗后2年阿霉素组有效率为81%,无水乙醇组为65%,组间差异有统计学意义(P<0.05)。结论阿霉素神经阻滞治疗原发性三叉神经痛远期疗效明显优于无水乙醇,且尤其适用于不能接受手术的三叉神经痛患者。
Objective To observe the clinical efficacy of doxorubicin block in the treatment of primary trigeminal neuralgia. Methods A total of 175 patients (209) with primary trigeminal neuralgia admitted to Department of Stomatology, Puyang Oilfield General Hospital from April 2008 to March 2011 were randomly divided into doxorubicin group (87 cases, 104 cases) and none Water ethanol group (88 cases, 105). Doxorubicin group with 1% doxorubicin nerve block, anhydrous ethanol group with ethanol block, observe the clinical effect and local reaction 7d after treatment, and followed up for 2 years. Results 7 days after treatment, 9 cases of local swelling, 10 cases of pain in the doxorubicin group and 26 cases of numbness in the nerve distribution area; 19 cases of local swelling in the ethanol group, 20 cases of pain, 36 cases of numbness in the nerve distribution area, The difference was statistically significant (P <0.05). The clinical efficacy of ADR group was 93% after 7 days of treatment, but there was no significant difference between the two groups (P> 0.05). The effective rate of Adriamycin group was 81 %, 65% ethanol group, the difference between the groups was statistically significant (P <0.05). Conclusion The long-term efficacy of adriamycin blockade in the treatment of primary trigeminal neuralgia is superior to absolute ethanol, and is especially suitable for patients with trigeminal neuralgia who can not undergo surgery.