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葡萄糖转运蛋白2(GLUT2)是胰岛β细胞的主要葡萄糖载体,在胰岛β细胞分泌胰岛素的过程中有重要的作用。GLUT2和葡萄糖激酶被认为是胰岛β细胞内的葡萄糖传感器,从而使体内胰岛素分泌反应的强度受血中葡萄糖浓度的调节。本文从GLUT2分子结构与功能、表达调控、与葡萄糖激酶关系、与糖脂毒性的关系和在糖尿病中的作用5个方面加以阐述。
Glucose transporter 2 (GLUT2) is a major glucose carrier of pancreatic β cells and plays an important role in the insulin secretion of pancreatic β cells. GLUT2 and glucokinase are thought to be glucose sensors in islet beta cells, so that the intensity of the insulin secretion response in the body is regulated by the glucose concentration in the blood. This article describes the five aspects of the structure and function of GLUT2, the regulation of expression, the relationship with glucokinase, the relationship with GLUThe glycoluria and the role in diabetes mellitus.