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目的:采用气相色谱法同时测定注射用头孢美唑钠中有机溶剂丙酮、异丙醇、甲基异丁基酮残留量的方法。方法:采用内标法顶空自动进样,在中极性弹性毛细管柱上进行分离,效果良好。结论:方法重现性好,定量准确,便于操作。结果:平均回收率:丙酮100.7%-104.3%;异丙醇95.8%-103.7%;甲基异丁基酮102.9%-104.3%变异系数:丙酮1.71%异丙醇2.49%甲基异丁基酮3.55%。
OBJECTIVE: To simultaneously determine the residual organic solvents acetone, isopropanol and methyl isobutyl ketone in cefmetazole sodium for injection by gas chromatography. Methods: The internal standard method of headspace automatic injection, in the polar flexible capillary column separation, the effect is good. Conclusion: The method is reproducible, accurate and easy to operate. Results: Average recovery: Acetone 100.7% -104.3%; Isopropanol 95.8% -103.7%; Methyl isobutyl ketone 102.9% -104.3% Coefficient of variation: Acetone 1.71% Isopropanol 2.49% Methyl isobutyl ketone 3.55%.