毛囊角化病系一少见的常染色体显性遗传性疾病,有关该病电镜下的病理改变,尚未见国内有报告。现将我们观察的3例报告如下: 1 病例及方法 组织取自同一家系的3位男性患者,年龄分别为43岁、36岁、18岁。皮损均为融合的扁平丘疹,伴轻度疣状改变。1例耳后取材,2例颈后取材。 方法:局麻后切取皮损组织。每例的组织分为3块:第1块作常规石蜡切片、HE染色。第2块以3％ Follicular hyperkeratosis is a rare autosomal dominant hereditary disease. There are no domestic reports on the pathological changes under electron microscope. The three cases we observed were reported as follows: 1 Cases and Methods Three male patients were recruited from the same family, aged 43 years, 36 years, and 18 years old respectively. The lesions were fused flat papules with mild verrucous changes. One case was drawn behind the ears, and two cases were drawn behind the neck. Methods: After local anesthesia, cut off the skin lesions. The tissue of each case was divided into 3 blocks: the first block was subjected to routine paraffin sections and HE staining. The second block is 3%