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目的总结本院不规则抗体阳性检出患者的抗体特异性及血液输注情况,保障临床用血安全。方法对全自动血型仪不规则抗体筛查阳性的样本,送市中心血站血液研究所做不规则抗体鉴定。再结合病历资料对临床用血情况及输注疗效进行综合分析。结果 23 473例患者样本中检出不规则抗体123例,阳性率为0.52%;其中非特异自身抗体阳性39例(占31.71%);特异性同种抗体阳性77例(占62.60%);自身抗体和同种抗体同时阳性7例(占5.69%)。61例不规则抗体阳性患者进行了输血治疗,除2例异体输血发生轻微过敏反应外,其余未发生输血不良反应,输血治疗有效。结论准确地进行不规则抗体筛查及特异性鉴定,选择合适的输血治疗方案,对于确保患者的输血安全和提高输血疗效具有重要的意义。
Objective To summarize the antibody specificity and blood transfusion in patients with irregular antibodies detected in our hospital to ensure the safety of clinical blood. Methods The samples of irregular antibody screening with automatic blood group instrument were sent to the Institute of Hematology, Shanghai Blood Center for irregular antibody identification. Combined with medical records on the clinical use of blood and infusion efficacy of a comprehensive analysis. Results Of the 23 473 samples, 123 cases were detected with irregular antibodies, the positive rate was 0.52%. There were 39 cases (31.71%) with nonspecific autoantibodies, 77 cases (62.60%) with specific alloantibodies, Antibodies and alloantibodies were positive in 7 cases (5.69%). 61 cases of irregular antibody-positive patients were transfused, except for 2 cases of slight allergic reactions of allogeneic blood transfusion, the remaining adverse reactions did not occur transfusion, blood transfusion is effective. Conclusion Accurate irregular antibody screening and specific identification, selection of appropriate blood transfusion regimen for ensuring the safety of blood transfusion and improve blood transfusion efficacy is of great significance.