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目的:考察注射用炎琥宁在静脉输液时与常用输液及药物的配伍变化。方法:按中国药典2010版测定配伍后的pH值、不溶性微粒变化,用高效液相色谱法测定含量变化。结果:注射用炎琥宁用pH值较低的10%葡萄糖注射液稀释,或与pH值相对较低的药物如维生素B_6输液、头孢硫脒静脉推注液等混合时产生浑浊、含量下降。结论:本品宜用0.9%的氯化钠注射液稀释,与pH值较低的注射液连续静脉滴注时各输液间要用0.9%的氯化钠注射液冲管。
OBJECTIVE: To investigate the changes of the compatibility of infusion of inhomoralin and intravenous infusion when used in infusion. Methods: According to the Chinese Pharmacopoeia 2010 edition after the determination of the compatibility of the pH, insoluble particles changes, determination of content by high performance liquid chromatography. Results: Yanhuoning injection with a lower pH value of 10% glucose injection dilution, or with the relatively low pH drugs such as vitamin B_6 infusion, cefathiamidine intravenous injection mixture turbidity, the content decreased. Conclusion: This product should be diluted with 0.9% sodium chloride injection, and when the infusion with lower pH value is injected intravenously with 0.9% sodium chloride injection.