中枢敏感化是疼痛形成的重要机制之一,超前镇痛作为防止中枢敏感化形成的方法已应用于临床。本文旨在探讨术前和术毕儿童硬膜外腔注射吗啡的镇痛效果及安全性。资料和方法择期ASA Ⅰ～Ⅱ级小儿骨科病儿60例,年龄6～10岁,行髋关节或股骨干手术。病儿均采用L_(2～3)硬膜外穿刺尾向置管,用1.2%利多卡因术中按需追加。随机选择20例在注射局麻药前20分钟经导管注入吗啡0.04mg·kg~(-1) Central sensitization is one of the important mechanisms of pain formation. Pre-analgesia has been used clinically as a method to prevent central sensitization. This article aims to explore the preoperative and postoperative children epidural morphine analgesic effect and safety. Materials and Methods Sixty ASA grade Ⅰ ~ Ⅱ pediatric orthopedics children, aged 6 to 10 years, underwent hip or femoral shaft surgery. Sick children were used L_ (2 ~ 3) epidural catheter caudal catheterization, with 1.2% lidocaine intraoperative need to add. Twenty patients were randomized to receive 0.04 mg · kg -1 of morphine via the catheter 20 minutes before the injection of local anesthetic.