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目的探讨营养支持治疗联合壮药复方合剂辅助治疗对艾滋病患者抗病毒治疗临床疗效的影响。方法收集自2015年1月至2015年10月在贵港市人民医院艾滋病门诊就诊未抗病毒治疗且合并营养不良的艾滋病患者80例,随机分为4组,每组各20例。分别给予抗病毒治疗(抗病毒组)、抗病毒治疗基础上加营养素治疗(营养辅助组),抗病毒治疗基础上加壮药治疗(壮药辅助组),抗病毒治疗联合营养素及壮药治疗(联合组),干预6个月。检测治疗前后患者肝肾功能、血常规,使用流式细胞仪检测治疗前后免疫细胞CD4~+、CD8~+淋巴细胞计数。结果治疗前各组研究对象血清白蛋白(SB)、谷丙转氨酶、肌酐、血红蛋白水平比较,差异无统计学意义(P>0.05)。治疗后营养辅助组、壮药辅助组、联合组血清白蛋白、血红蛋白水平较抗病毒组高,联合组SB、血红蛋白水平较营养辅助组及壮药辅助组高,壮药辅助组及联合组转氨酶水平较抗病毒组、营养辅助组低,联合组肌酐水平较抗病毒组、营养辅助组低,差异有统计学意义(P<0.05)。治疗前各组CD4~+、CD8~+T淋巴细胞水平差异无统计学意义(P>0.05)。治疗后抗病毒组、营养辅助组、壮药辅助组、联合组CD4~+T淋巴细胞水平分别为(259.8±123.81)、(376.3±110.43)、(393.9±136.08)、(487.9±117.64)/μL,CD8~+T淋巴细胞水平分别为(715.1±174.73)、(654.7±185.50)、(669.9±207.89)、(689.1±156.03)/μL。治疗后各组CD4~+T淋巴细胞水平差异有统计学意义(F=11.714,P<0.05),其中营养辅助组、壮药辅助组、联合组CD4~+T淋巴细胞水平较抗病毒组高,联合组CD4~+T淋巴细胞水平较营养辅助组、壮药辅助组高,差异均有统计学意义(P<0.05)。治疗后各组CD8~+T淋巴细胞水平差异无统计学意义(P>0.05)。结论营养支持及壮药辅助治疗有利于改善抗病毒治疗的艾滋病患者营养状况及促进免疫重建,对艾滋病的治疗具有协同作用。
Objective To investigate the effect of nutrition supportive therapy combined with Zhuangyao Compound on adjuvant therapy on the clinical efficacy of antiviral therapy in AIDS patients. Methods From January 2015 to October 2015, 80 cases of AIDS patients without AIDS treatment and malnutrition in AIDS clinics of Guigang People’s Hospital were randomly divided into 4 groups with 20 cases in each group. Antiviral therapy (antivirus group), antiviral therapy plus nutritional therapy (nutritional support group), antiviral therapy based on strong Zhuang drug (Zhuangyao Auxiliary group), antiviral combination therapy and Zhuangyao (Joint group), intervention for 6 months. The liver and kidney function and blood routine of patients before and after treatment were detected. The count of CD4 ~ + and CD8 ~ + lymphocytes in immune cells before and after treatment were detected by flow cytometry. Results Before treatment, there was no significant difference in serum albumin (SB), alanine aminotransferase, creatinine and hemoglobin between the two groups (P> 0.05). After treatment, nutritional supplementation group, Zhuangyao auxiliary group, combined group serum albumin, hemoglobin levels higher than the antiviral group, combined group SB, hemoglobin levels higher than the nutritional support group and Zhuang drug auxiliary group, Zhuang drug auxiliary group and the combination group transaminase The level of creatinine in the combined group was lower than that in the antiviral group and the nutritional support group (P <0.05). Before treatment, the levels of CD4 ~ +, CD8 ~ + T lymphocytes in each group had no significant difference (P> 0.05). After treatment, the levels of CD4 ~ + T lymphocytes in antiviral group, nutritional support group, Zhuangyao auxiliary group and combined group were (259.8 ± 123.81), (376.3 ± 110.43), (393.9 ± 136.08) and (487.9 ± 117.64) / μL and CD8 ~ + T lymphocytes were (715.1 ± 174.73), (654.7 ± 185.50), (669.9 ± 207.89) and (689.1 ± 156.03) / μL, respectively. After treatment, the levels of CD4 ~ + T lymphocytes in each group were significantly different (F = 11.714, P <0.05). The levels of CD4 ~ + T lymphocytes in the nutritional support group, the Zhuangyao auxiliary group and the combined group were significantly higher than those in the antiviral group , While the level of CD4 ~ + T lymphocytes in the combined group was higher than that in the nutritional support group and the Zhuangyao auxiliary group (P <0.05). After treatment, the levels of CD8 ~ + T lymphocytes in each group had no significant difference (P> 0.05). Conclusion Nutritional support and Zhuangyao adjuvant therapy are beneficial to improve the nutritional status of patients with AIDS and to promote immune reconstitution of antiviral therapy and have a synergistic effect on the treatment of AIDS.