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治疗消化性溃疡,口服抗酸剂及H_2-受体拮抗剂甲氰咪胍为两种主要方法。临床上,对一般病人的治疗常需合用这两药,尤其是在溃疡治疗初期或夜间治疗,为了缓解疼痛更为常用。抗酸剂与甲氰咪胍之间的相互作用尚未阐明,曾有报道(Steinberg ＆Lewis 1980),两者间无相互作用,也不影响其吸收。虽然抗酸剂可减少多种其他药物 的吸收,但对此尚未发表过足够的研究资料。 灭吐灵为一胃肠道平滑肌兴奋剂;能加速胃的排空,并可增加多种药物的吸收率,但却减少狄戈辛的吸收率。灭吐灵在治疗胃滞留及反流性食道炎时常与甲氰咪胍合用。为此,作者研究了它们各自合用时在人体内吸收的相互影响。 8例(男7,女1)健康志愿受试者,平均
Treatment of peptic ulcer, oral antacids and H 2 -receptor antagonist cimetidine are the two main methods. Clinically, the general treatment of patients often need to use these two drugs, especially in the early treatment of ulcers or night treatment, in order to ease the pain more commonly used. The interaction between antacids and cimetidine has not been elucidated and it has been reported (Steinberg & Lewis 1980) that there is no interaction between them and their absorption is not affected. Although antacids can reduce the absorption of many other drugs, but not enough research published on this information. Metoclopramide is a gastrointestinal smooth muscle stimulant; can accelerate the gastric emptying, and can increase the absorption rate of a variety of drugs, but reduce the absorption rate of Dioxin. Metoclopramide in the treatment of gastric retention and reflux esophagitis often cimetidine combined. To this end, the authors studied the interaction between the two in the human body when they were used in combination. 8 (male 7, female 1) healthy volunteers, average