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测定25例正常孕妇，22例中度或重度妊高征病人的血浆蛋白C活性（Pc：C）和蛋白e抗原（Pc：Ag）及组织纤溶酶原激活物抗原（t－PA：Ag）的水平，以20例非孕妇作对照。结果表明：正常孕妇血浆Pc：C为1570％±38．1％，Pc：Ag为7．22±2．3μg／L；妇高征病人Pc：C为193.5％±66％，Pc：Ag为6.96±2.27μg／L；两组呈同步升高（P＞0．05），与非孕组（Pc：c为100.9％±25.3％，Pc：Ag为4.66±1．6μg／L）比较，差异显著（P＜0．001）．t－PA：Ag妇高征组为15.6±11.08μg／L，正常孕妇为8±5.8μg／L，与非孕组（2．02±1．013μg／L）比较，差异显著（P＜0.001）．表明在妊娠后期，特别是妇高征时，孕妇的抗凝与纤溶系统有明显改变。
The plasma protein C activity (Pc: C), protein e antigen (Pc: Ag) and tissue plasminogen activator (t-PA: Ag) in 25 normal pregnant women and 22 moderate- ) Levels, with 20 cases of non-pregnant women as a control. The results showed that the Pc: C of normal pregnant women was 1570% ± 38.1% and that of Pc: Ag was 7.22 ± 2.3μg / L. The Pc: C of women with preeclampsia was 193.5% ± 66% 6.96 ± 2.27μg / L, respectively. Compared with non-pregnant group (Pc: c = 100.9% ± 25.3%, Pc: Ag = 4.66 ± 1.6μg / L) The difference was significant (P <0.001). There was significant difference (P <0.001) between women with t-PA and women with non-pregnant (2.02 ± 1.013μg / L) ). That in the late pregnancy, especially in women with hyperlipidemia, pregnant women, anticoagulant and fibrinolytic system has changed significantly.