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为了从氰基丙烯酸酯类衍生物中寻找新的活性化合物,通过活性亚结构拼接方法,设计并合成了一系列未见文献报道的新型含取代嘧啶结构的氰基丙烯酸酯类化合物.其结构均经核磁共振氢谱、碳谱和元素分析确证.初步的生物活性测试结果表明,部分目标化合物显示出较好的除草活性.在1500 g/ha剂量下,化合物9a和9b对芥菜的茎叶处理除草活性分别为90%和100%,化合物9a和9b对繁缕的茎叶处理除草活性分别为90%和100%,化合物9a和9b对小藜的茎叶处理除草效果分别为95%和100%;此外,化合物9b在750 g/ha剂量下对芥菜、繁缕及小藜茎叶处理抑制率均达100%,化合物9b在375 g/ha剂量下对芥菜、繁缕及小藜茎叶处理抑制率分别为90%,80%和90%.
In order to search for new active compounds from cyanoacrylate derivatives, a series of novel novel substituted pyrimidine-containing cyanoacrylates have been designed and synthesized by active substructural splicing The results of 1H NMR, GC and elemental analysis confirmed that the preliminary bioassay results showed that some of the target compounds showed good herbicidal activities.Compounds 9a and 9b were also effective for the treatment of mustard stems and leaves at 1500 g / ha The herbicidal activities of herbicides were 90% and 100% respectively. The herbicidal activities of compounds 9a and 9b on the stems and leaves of P. chinensis were 90% and 100%, respectively. The herbicidal effects of compounds 9a and 9b on the leaf and stems of Chenopodium glaucum were 95% and 100% %. In addition, the inhibitory rate of compound 9b on the treatment of mustard, chickweed and quinoa leaf stems and leaves was both 100% at 750 g / ha, while that of compound 9b on mustard, Treatment inhibition rates were 90%, 80% and 90% respectively.