论文部分内容阅读
目的：探讨大承气汤保护肠道屏障功能、治疗内毒素血症的理论。方法：体外实验选用大鼠肝溶酶体，体内实验选用内毒素所致家兔全身性施瓦茨曼反应（ＧＳＲ）作为弥漫性血管内凝血（ＤＩＣ）模型，并给予不同处理，借测定溶酶体标志酶——酸性磷酸酶（ＡＣＰ）活性，以判断溶酶体膜是否完整及大承气汤对其保护作用。结果：模型组动物肝、肠溶酶体ＡＣＰ活性明显升高，而大承气汤治疗组则与正常对照组相似。结论：大承气汤能够稳定肝、肠溶酶体膜，减少溶酶外逸，拮抗内毒素对机体的损害
Objective: To explore the theory of Dachengqi Decoction protecting intestinal barrier function and treating endotoxemia. METHODS: Rat hepatic lysosomes were used in vitro. In vivo, rabbits were treated with endotoxin-induced systemic Schwarzmann reaction (GSR) as a model of disseminated intravascular coagulation (DIC) and given different treatments. The enzymatic marker enzyme, acid phosphatase (ACP) activity, was used to determine whether the lysosomal membrane was intact and the protective effect of Dachengqi Decoction. RESULTS: The activity of ACP in liver and intestinal lysosomes of the model group was significantly increased, while the Dachengqi Decoction treatment group was similar to the normal control group. Conclusion: Dachengqi Decoction can stabilize liver and intestinal lysosome membrane, reduce lysozyme escape, and antagonize the damage of endotoxin to the body.