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目的研究耐甲氧西林金黄色葡萄球菌(MRSA)医院感染情况及其耐药性监测。方法通过病原学标本分离鉴定技术和药敏试验方法,对某医院住院患者送检标本进行了分离鉴定及药敏试验。检出的MRSA按照标本来源、科室分布、药物耐药性等进行分析。结果该医院在2011-2012年从医院感染患者送检标本中共检出耐甲氧西林金黄色葡萄球菌95株,主要分离自痰液(占48.42%),其次是血液和伤口分泌物。MRSA感染患者主要分布于重症监护病房和神经外科,分别占29.47%和15.79%。MRSA除对万古霉素和利奈唑胺敏感外,对大环内酯类、氨基糖苷类、喹诺酮类及磺胺类药物呈不同程度耐药性。结论 MRSA主要分离自重症病房的呼吸道感染患者,其耐药情况比较严重,应加强有效控制措施。
Objective To study the surveillance and surveillance of methicillin-resistant Staphylococcus aureus (MRSA) hospital infection. Methods Through the separation and identification of etiological specimens and drug susceptibility testing methods, the specimens of hospitalized patients in a hospital were isolated and identified and tested for susceptibility. MRSA detected in accordance with the source of specimens, departmental distribution, drug resistance analysis. Results The hospital detected 95 strains of methicillin-resistant Staphylococcus aureus from sputum (accounting for 48.42%), followed by blood and wound secretions from 2011 to 2012. The patients with MRSA were mainly distributed in intensive care unit and neurosurgery, accounting for 29.47% and 15.79% respectively. MRSA in addition to vancomycin and linezolid sensitive, macrolides, aminoglycosides, quinolones and sulfa drugs showed varying degrees of resistance. Conclusions MRSA is mainly isolated from patients with respiratory tract infection in intensive care unit, and its drug resistance is rather serious. Effective control measures should be strengthened.