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目的:探讨T细胞受体保守域α链基因(TCRCα)-575 A/G多态性与中国汉族人群IgA肾病临床病理的相关关系.方法:PCR-RFLP法和PCR产物直接测序法鉴定基因型,对IgA肾病患者的临床及病理资料进行相关分析,并对病例进行追踪随访.结果:①291例患者临床资料分析显示:在伴有肉眼血尿患者中AA基因型的出现频率显著性升高(P<0.05);在年龄、性别、血压、血尿、蛋白尿、血清IgA水平等临床指标中任何基因型的分布频率均无统计学意义(P>0.05).②294例患者病理资料分析显示:在IgA肾病Haas分级的Ⅱ+Ⅲ级的患者中,AA基因型其分布频率相对于其他基因型有显著增加(P<0.05).③219例IgA肾病患者,TCRCα基因-575 A/G不论是基因型还是等位基因,在肾功能稳定组与进展组相比较均未见显著性差异(P>0.05).结论:中国汉族人群中,TCRCα基因-575 A/G多态性可能和肉眼血尿的发生、系膜增生相关,但可能与肾功能进展不相关.
Objective: To investigate the relationship between the TCRCα -575 A / G polymorphism and the clinicopathological features of IgA nephropathy in Chinese Han population.Methods PCR-RFLP and PCR products were used to identify the genotype , The clinical and pathological data of patients with IgA nephropathy were analyzed and followed up.Results: ① The clinical data of 291 patients showed that the frequency of AA genotype was significantly increased in patients with gross hematuria (P <0.05). The distribution frequency of any genotype in clinical indexes such as age, gender, blood pressure, hematuria, proteinuria, serum IgA level had no statistical significance (P> 0.05) .②The pathological data of 294 patients showed that: Among the 119 cases with IgA nephropathy, the distribution frequency of AA genotype was significantly higher than that of other genotypes (P <0.05) .219 cases of IgA nephropathy, TCRCα -575 A / G, whether genotype or There were no significant differences in alleles between the stable renal function group and the progression group (P> 0.05) .Conclusion: The -575 A / G polymorphism of TCRCα gene may be associated with gross hematuria, Mesangial proliferation related, but may be related to kidney function Can not progress.