论文部分内容阅读
目的 了解鹤壁市新发初治肺结核病人初始耐药情况 ,分析耐药原因 ,提出降低耐药措施。方法 选择 1993年— 1999年门诊收治的新发初治涂阳培阳肺结核病人 2 12例 ,测定异烟肼 (H)、链霉素 (S)、利福平 (R)、对氨基水杨酸钠 (P)、乙胺丁醇(E)的初始耐药情况。结果 7年间选择的 2 12例患者中 ,初始耐药 88例 ,平均初始耐药率为 41.5 % ,初始耐药率有逐年增高趋势。初始耐药率以S最高 ( 2 9.2 % ) ,依次为R( 2 1.7% )、H( 2 0 .8% )、E( 17.0 % )、P( 9.4% )。单耐者 17.0 % ,双耐者 18.8% ,耐3药者 4.7% ,耐 4药者 0 .9%。结论 鹤壁市属于初始耐药较高地区。产生原因主要为治疗管理不善和病人无钱就医。加强肺结核病人的归口管理 ,推行全程督导化疗是降低初始耐药的关键措施
Objective To understand the initial resistance of newly diagnosed pulmonary tuberculosis patients in Hebi City, analyze the causes of drug resistance and propose measures to reduce drug resistance. Methods Two hundred and twenty-two newly diagnosed smear-positive pulmonary tuberculosis patients were selected from outpatients in our hospital from 1993 to 1999. The levels of isoniazid (H), streptomycin (S), rifampicin (R) Sodium acid (P), ethambutol (E) initial resistance. Results Among the 2 12 patients selected during the 7 years, the initial drug resistance was 88 and the average initial drug resistance rate was 41.5%. The initial drug resistance rate increased year by year. The initial resistance rate was S (2 9.2%), followed by R (2 1.7%), H (20.8%), E (17.0%) and P (9.4%). Single resistance 17.0%, 18.8% of dual resistance, resistance to 3 drug users 4.7%, resistant to 4 drug users 0.9%. Conclusion Hebi City belongs to areas with high initial resistance. The main causes of poor management and treatment of patients with no money for medical treatment. Strengthening the centralized management of tuberculosis patients and implementing the whole-course supervision and chemotherapy are the key measures to reduce the initial resistance