前体药物 (简称前药 )为一类在体外活性较小或无活性 ,在体内经过酶或非酶作用 ,释放出活性物质而发挥药理作用的化合物。与母体药物相比 ,前药具有提高生物利用度 ,增加水溶性 ,延长作用时间 ,减少不良反应 ,克服首过效应 ,定位到达靶器官等特性。本文对抗病毒前体药物研究进展作介绍。 Prodrugs (referred to as prodrugs) are a class of compounds that exhibit pharmacological effects in vitro with less or no activity, enzymatic or non-enzymatic action in the body, and release of active substances. Compared with the parent drug, the prodrug has the characteristics of improving the bioavailability, increasing the water solubility, prolonging the action time, reducing the adverse reaction, overcoming the first pass effect and locating the target organ. This article describes the progress of anti-viral prodrugs.