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目的 探讨血清中胰岛素样生长因子I(IGF I)水平与乳腺肿瘤的发生可能存在的关系。方法 使用肝脏特异性IGF I基因缺失 (LID)小鼠 ,其循环中IGF I水平仅为正常小鼠 (对照组小鼠 )的 2 5 % ,用化学致癌剂 7,12 二甲基苯蒽 (DMBA)诱导原发性乳腺肿瘤。结果 与对照组相比 ,LID鼠乳腺肿瘤的潜伏期均明显延长 ,LID小鼠可触及的乳腺肿瘤发病率明显下降 (2 6% /5 6% ) ,其肿瘤的出现也明显延迟 [(74.0± 1.2 )d/(5 9.5± 1.1)d]。结论 在致癌剂DMBA诱导的乳腺肿瘤模型中 ,IGF I作为一种危险因子 ,其血液中的水平对乳腺肿瘤的发生和发展起重要作用。
Objective To investigate the relationship between the level of insulin-like growth factor I (IGF-I) in serum and the possible occurrence of breast cancer. METHODS: Liver-specific IGF I gene deletion (LID) mice were used. The circulating IGF-I level was only 25% of that of normal mice (control mice), and 7,12-dimethylbenzyl anthracene DMBA) induces primary breast tumors. Results Compared with the control group, the latency of mammary tumors in LID mice was significantly prolonged. The incidence of palpable breast tumors was significantly decreased in LID mice (26% / 56%), and the incidence of tumors was significantly delayed [(74.0 ± 1.2) d / (5 9.5 ± 1.1) d]. Conclusions IGF I is a risk factor in DMBA-induced mammary tumor model, and its blood level plays an important role in the occurrence and development of breast cancer.