对２０例恶性脑膜瘤作了Ⅰ，Ⅲ，Ⅳ型胶原及ｌａｍｉｎｉｎ，ｆｉｂｒｏｎｅｃｔｉｎ的免疫组化染色。Ⅳ型胶原及Ｌａｍｉｎｉｎ在血管基膜呈连续线状阳性，阳性物多于良性脑膜瘤，基膜增厚分层；Ⅰ，Ⅲ型胶原明显减少，仅在巢间间质内呈稀网状，条状阳性。结果提示上述改变可作为良恶性的鉴别点之一；基膜增厚也可能是恶性脑膜瘤不易经血道转移的一种原因。 Immunohistochemical staining of collagen type Ⅰ, Ⅲ, Ⅳ, laminin and fibronectin was performed on 20 cases of malignant meningiomas. Type Ⅳ collagen and Laminin showed a continuous linear pattern in the vascular basement membrane. The positive ones were more than benign meningioma and the basement membrane was thickened and stratified. Collagen types Ⅰ and Ⅲ were significantly reduced, Strip positive. The results suggest that the above changes can be used as one of the distinguishing points of benign and malignant. The thickening of the basement membrane may also be one reason that malignant meningioma is not easily metastable.