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目的评价联合应用潘托拉唑与复方铝酸铋预防急性冠脉综合征后上消化道出血的疗效。方法将2006—2008年住院的急性冠脉综合征患者167例纳入本组研究,其中男147例、女20例,年龄47-85岁,平均(73±12)岁,随机分为联合治疗组(n=51)、潘托拉唑组(n=61)和复方铝酸铋组(n=55)。急性冠脉综合征常规治疗的方法相同。观察3组并发上消化道出血的发生率。结果 3组急性冠脉综合征后上消化道出血的发生率分别为:潘托拉唑组13.11%、复方铝酸铋组20.0%、联合治疗组3.92%。联合治疗组上消化道出血的发生率明显降低(P<0.05)。结论急性冠脉综合征后联合应用胃黏膜保护剂与质子泵抑制剂可以更加有效预防上消化道出血。
Objective To evaluate the efficacy of combination of pantoprazole and compound bismuth aluminate in the prevention of upper gastrointestinal bleeding after acute coronary syndrome. Methods One hundred and sixty-seven patients with acute coronary syndrome admitted in our hospital from 2006 to 2008 were enrolled in this study, including 147 males and 20 females, aged 47-85 years, mean (73 ± 12) years and were randomly divided into combined treatment group (n = 51), pantoprazole group (n = 61) and compound bismuth aluminate group (n = 55). Acute coronary syndrome routine treatment the same way. The incidence of upper gastrointestinal bleeding in 3 groups was observed. Results The incidence of upper gastrointestinal bleeding after acute coronary syndrome in the three groups were 13.11% in the group of pantoprazole, 20.0% in the compound bismuth aluminate group and 3.92% in the combination group. The incidence of upper gastrointestinal bleeding in the combination therapy group was significantly lower (P <0.05). Conclusions Combination of gastric mucosal protective agent and proton pump inhibitor after acute coronary syndrome can prevent upper gastrointestinal bleeding more effectively.