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[目的]探讨多肿瘤标志物蛋白芯片技术在人群防癌普查中的应用价值。[方法]采用多肿瘤标志物蛋白芯片技术对5 126人进行12种肿瘤相关抗原物的普查。[结果]5 126例中筛查出271例肿瘤标志物阳性,总阳性检出率为5.3%,其中15例被病理学、内窥镜、影像学确认为早期或中期肿瘤。肿瘤检出率为0.29%。[结论]多肿瘤蛋白芯片检测技术具有高信息量,简捷、快速、高效等优点,适用于无症状人群及高危人群的普查。
[Objective] To investigate the value of multi-tumor marker protein chip technology in the crowd anti-cancer screening. [Method] The multi-tumor marker protein chip technology was used to screen 1226 tumor-associated antigens in 5 126 people. [Results] Totally 271 cases of tumor markers were screened out from 5 126 cases, and the total positive detection rate was 5.3%. Fifteen of them were confirmed by pathology, endoscopy and imaging as early or middle stage tumors. Tumor detection rate was 0.29%. [Conclusion] The multi-oncoprotein microarray detection technique has the advantages of high informativeness, simplicity, rapidness and high efficiency, and is suitable for asymptomatic and high-risk population screening.