AIM:To investigate whether Helicobacter pylori(H.pylori) infection is associated with glycemic control and whether hyperglycemia is modified by eradication therapy.METHODS:The databases of Pub Med,Cochrane Library,Chinese Bio Medicine Web Base and Chinese Science and Technology Journals were searched from inception to June 2014.Studies examining the association between H.pylori infection and glycemic control and/or the effect of eradication treatment on glycemic control in diabetic humans were eligible for inclusion.Meta-analyses were conducted using the Review Manager software version 5.2.The outcome measures are presented as weighed mean differences(WMDs) with 95% confidence intervals(CIs).Statistical heterogeneity was assessed by the Cochran Q test and the I2 statistic.RESULTS:A total of 21 relevant publications were identified.A meta-analysis of 11 studies with 513 patients with diabetes mellitus(DM) showed significantly lower glycosylated hemoglobin(Hb A1c) levels in the H.pylori-negative than H.pylori-positive DM participants(WMD = 0.43,95%CI:0.07-0.79;P = 0.02).In children and adolescents with type 1 DM(T1DM),there was a positive association between H.pylori infection and Hb A1 c level(WMD = 0.35,95%CI:0.05-0.64;P = 0.02),but there was no difference in those with type 2 DM(T2DM,WMD = 0.51,95%CI:-0.63-1.65;P = 0.38).A meta-analysis of six studies with 325 T2 DM participants showed a significant difference in the fasting plasma glucose levels between H.pylori-positive and H.pylori-negative participants(WMD = 1.20,95%CI:0.17-2.23;P = 0.02).Eradication of H.pylori did not improve glycemic control in the T2 DM participants in a threemonth follow-up period(Hb A1 c decrease:WMD =-0.03,95%CI =-0.14-0.08;P = 0.57;fasting plasma glucose decrease:WMD =-0.06,95%CI:-0.36-0.23;P = 0.68).Glycemic control was significantly better in T1 DM participants who were not reinfected than in those who were reinfected(Hb A1c:WMD = 0.72,95%CI:0.32-1.13:P = 0.00).CONCLUSION:H.pylori infection is associated with poorer glycemic control in T1 DM patients,but eradication may not improve glycemic control in DM in a short-term follow-up period. AIM: To investigate whether Helicobacter pylori (H. pylori) infection is associated with glycemic control and whether hyperglycemia is modified by eradication therapy. METHODS: The databases of Pub Med, Cochrane Library, Chinese Bio Medicine Web Base and Chinese Science and Technology Journals were searched from inception to June 2014. Judies examining the association between H. pylori infection and glycemic control and / or the effect of eradication treatment on glycemic control in diabetic humans were eligible for inclusion. Meta-analyzes were conducted using the Review Manager software version 5.2 The outcome measures are presented as weighed mean differences (WMDs) with 95% confidence intervals (CIs). Statistical heterogeneity was assessed by the Cochran Q test and the I2 statistic .RESULTS: A total of 21 relevant publications were identified. A meta- analysis of 11 studies with 512 patients with diabetes mellitus (DM) showed significantly lower glycosylated hemoglobin (Hb A1c) levels in the H.pylori- negative than H. pylori-positive DM participants (WMD = 0.43, 95% CI: 0.07-0.79; P = 0.02). In children and adolescents with type 1 DM (T1DM), there was a positive association between H. pylori infection and Hb A1 c level (WMD = 0.35, 95% CI: 0.05-0.64; P = 0.02) but there was no difference in those with type 2 DM (T2DM, WMD = 0.51, 95% CI: -0.63-1.65; P = 0.38). A meta-analysis of six studies with a significant difference in the fasting plasma glucose levels between H. pylori-positive and H. pylori-negative participants (WMD = 1.20, 95% CI: 0.17- 2.23; P = 0.02). Eradication of H. pylori did not improve glycemic control in the three-month follow-up period (Hb A1 c decrease: WMD = -0.03, 95% CI = -0.14-0.08; P = 0.57; fasting plasma glucose decrease: WMD = -0.06, 95% CI: -0.36-0.23; P = 0.68). Glycemic control was significantly better in T1 DM participants who were not reinfected than those who who were reinfected (Hb A1c: WMD = 0.72, 95% CI: 0.32-1.13: P = 0.00) .CONCLUSION: H. pylori infection is associated with poorer glycemic control in T1 DM patients, but eradication may not improve glycemic control in DM in a short-term follow-up period.