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中国已经成为了世界上抗生素原料药生产的主要国家之一,青霉素菌渣产生量大、不易处理,而且是危险固体废物,为减少其对环境的危害,对其嗜热溶胞菌生物减量化进行了研究,考察了温度及嗜热溶胞菌液含量对其减量化效果的影响。实验结果表明:嗜热溶胞菌能有效提高菌渣胞内有机物的溶出,接种10%嗜热溶胞菌,在50、60和70℃下SS、SCOD和NH_4~+-N的结果表明:60℃条件下减量效果最好,SS去除率达到32.47%,SCOD由1 015 mg/L增长到1 714 mg/L,NH_4~+-N增量最高,达2.71 mg/L。接种0%、5%、10%、15%和20%嗜热溶胞菌在60℃下SS、SCOD和NH_4~+-N的结果表明:菌液含量为5%时,SS去除率较高,SCOD最大值达1 726 mg/L,加菌下的NH_4~+-N浓度要高于未加菌下的NH_4~+-N浓度。可见,在适宜的条件下,嗜热溶胞菌对青霉素菌渣具有减量化效果,且在60℃,菌液含量为5%时减量效果最佳。
China has become one of the major countries in the world in the production of antibiotic drug substances. Penicillin bacteria scum is produced in a large amount and is not easy to handle. It is also a hazardous solid waste. To reduce its harm to the environment, The study was conducted to investigate the effects of temperature and thermophilic bacterium lysate on its quantification. The results showed that thermophilic bacterium could effectively increase the intracellular leaching of organism, and 10% thermophilic bacilli were inoculated. The results of SS, SCOD and NH_4 ~ + -N at 50, 60 and 70 ℃ showed that: The removal rate of SS was 32.47% at 60 ℃, SCOD increased from 1 015 mg / L to 1 714 mg / L, and NH 4 + -N was the highest, reaching 2.71 mg / L. SS, SCOD and NH_4 ~ + -N of 0, 5, 10, 15 and 20% of thermophilic bacilli inoculated at 0 ℃, 5 ℃, 5 ℃, 60 ℃ showed that the SS removal rate was higher when the bacterial content was 5% , SCOD reached a maximum value of 1 726 mg / L, and the concentration of NH 4 + -N in the added bacteria was higher than that of NH 4 + -N in non-added bacteria. Visible, under suitable conditions, the thermophilic bacterium to penicillin bacteria residue with a reduction effect, and at 60 ℃, bacterial liquid content of 5% when the best amount of reduction.