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目的对注射用奥扎格雷钠(丹奥)和低分子肝素联合治疗效果进行比较观察,探讨脑梗死的疗效和安全性。方法选取2009年6月-2011年6月急性进展性脑梗死患者110例,将110例患者随机分为治疗组(55例)与对照组(55例),两组患者均给予基础治疗,对照组加用精制蝮蛇抗栓酶,治疗组加用药物低分子肝素钙与丹奥。对两组患者的治疗效果进行对比。结果治疗组中有效率92.7%,对照组中有效率70.9%,两组疗效的差异具有统计学意义,P<0.05。观察组患者治疗后3d、7d、14d的神经功能缺损的程度评分明显低于对照组。结论在治疗进展性脑梗死中,根据研究设计,注射用奥扎格雷钠(丹奥)联合低分子肝素治疗效果要比蝮蛇抗栓酶好一些,在常规治疗基础上加用药物丹奥联合低分子肝素,能明显有效地扩张脑部血管,降低血液的粘稠度,有效地抗凝抗血小板聚集,达到改善局部缺血的症状,多方面降低脑梗死进展程度,临床治疗效果较好,安全可靠,应该在临床上推广使用。
Objective To compare the therapeutic effect of ozagrel sodium (Danao) and low molecular weight heparin for injection in order to investigate the curative effect and safety of cerebral infarction. Methods 110 patients with acute progressive cerebral infarction from June 2009 to June 2011 were selected and 110 patients were randomly divided into treatment group (55 cases) and control group (55 cases). Both groups were given basic treatment. The control group Group plus purified viper antithrombotic enzyme, the treatment group plus drug low molecular weight heparin and Danao. The treatment effect of two groups of patients were compared. Results The effective rate was 92.7% in the treatment group and 70.9% in the control group, the difference between the two groups was statistically significant (P <0.05). The score of neurological deficit in the observation group at 3d, 7d and 14d after treatment was significantly lower than that of the control group. Conclusion In the treatment of progressive cerebral infarction, according to the study design, the injection of sodium ozagrel (Danao) combined with low molecular weight heparin therapy is better than viper snake antithrombotic enzyme, based on the conventional treatment with the drug Danao Union Low molecular weight heparin, can significantly and effectively expand the blood vessels of the brain, reduce blood viscosity, effective anticoagulant anti-platelet aggregation, to improve the symptoms of ischemia, reduce the progress of cerebral infarction in many aspects, the clinical treatment effect is better, Safe and reliable, it should be widely used in clinical practice.