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1951年,Ducci 和 Motlis 首次报道肾上腺皮质激素(以下简称激素)治疗暴发型病毒性肝炎获得意外疗效。过去认为激素具有非特异性抗炎作用,使黄疸消退较快和改善症状。但经长期观察表明,激素对病毒性肝炎患者肝细胞的病理变化和病程转归疗效并不显著,并有增加肝内脂肪含量作用;无预防慢性肝损伤的功效;不能防止生发肝功能衰竭及肝性脑病。有人认为应用激素后病人的复发
In 1951, Ducci and Motlis first reported adrenal cortex hormones (hereinafter referred to as hormones) for the treatment of fulminant viral hepatitis to obtain an unexpected effect. In the past that hormones have a non-specific anti-inflammatory effect, jaundice faded faster and improve symptoms. However, after long-term observation shows that the hormone in patients with viral hepatitis pathological changes of liver cells and the course of the curative effect is not significant, and increase the role of intrahepatic fat; no effect in preventing chronic liver injury; can not prevent germinal liver failure and Hepatic encephalopathy. Some people think that the application of hormones after the patient’s recurrence