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目的观察降钙素原水平在成人呼吸机相关肺炎中的变化特点。方法将呼吸机相关肺炎患者120例按照7d内是否机械通气分组,试验组60例7d内进行了机械通气,对照组60例7d内未机械通气。在机械通气前和机械通气7d后测定2组患者血清降钙素原水平、白细胞数(WBC)、血清C反应蛋白(CRP)水平。结果试验组机械通气后血清降钙素原水平为(0.268±0.04)ng/ml高于对照组的(0.145±0.01)ng/ml(P<0.05)。治疗后试验组患者WBC高于对照组,血清CRP水平低于对照组,差异均有统计学意义(P<0.05)。结论成人呼吸机相关肺炎患者降钙素原水平较高,对降钙素原水平进行及时的检测,可供成人呼吸机相关肺炎的诊断和及时治疗参考。
Objective To observe the changes of procalcitonin in adult ventilator-associated pneumonia. Methods 120 patients with ventilator-associated pneumonia were divided into groups according to whether they were ventilated within 7 days or not, and 60 patients in experimental group were given mechanical ventilation within 7 days. Sixty patients in control group were not ventilated within 7 days. Serum procalcitonin, WBC and CRP levels were measured before mechanical ventilation and after 7 days of mechanical ventilation. Results The level of procalcitonin (0.268 ± 0.04) ng / ml in the experimental group after mechanical ventilation was significantly higher than that in the control group (0.145 ± 0.01) ng / ml (P <0.05). After treatment, WBC in test group was higher than that in control group, serum CRP level was lower than that in control group, the difference was statistically significant (P <0.05). Conclusions The level of procalcitonin in adult patients with ventilator-associated pneumonia is higher, and the level of procalcitonin is detected in time, which can be used as reference for the diagnosis and timely treatment of adult ventilator-associated pneumonia.