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应用抗肿瘤药物作为外科癌症病人辅助性治疗,近25年来已成普遍的事。但由于这些药物选择性抑制最活跃的增殖细胞群,是否对创口愈合也起有害作用,是值得提出的问题。许多实验证明:氮芥等烃基化药物,能减低创口愈合能力,抑制创面收缩和减少胶原纤维产生。家兔应用此药,伤后第三日创区肉芽组织成伤和胶原含量明显减少,创口收缩延迟。Desprez等证明环磷酰胺类药有减低创口破裂强度作用,减弱程度随药量的增加而增加。Wie氏等实验证明用该药后创口上皮新生率自60％降低7％。抗肿瘤抗菌素类药对创口恢复期都具有抑制细胞分裂,减低成纤维细胞和胶原形成。
The application of antineoplastic drugs as adjuvant therapy for surgical cancer patients has become a common occurrence in the past 25 years. However, whether these drugs selectively inhibit the most active proliferating cell population may also have detrimental effects on wound healing is a question worth asking. Many experiments show that: nitrogen mustard and other hydrocarbyl drugs, can reduce wound healing, inhibit wound contraction and reduce collagen production. Rabbits using this drug, wound granulation tissue injury and collagen content was significantly reduced on the third day after injury, wound contraction delayed. Desprez et al proved that cyclophosphamide drugs have the effect of reducing the wound rupture strength, the degree of attenuation increases with the increase of the dose. Wie’s experiments show that with the drug wound epithelial newborn rate decreased by 60% from 7%. Antitumor antibiotics can restrain cell division and reduce formation of fibroblasts and collagen during recovery period.