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在脑膜炎的治疗中,根据抗菌素给药的途径。绝大部分是很容易治疗的,在脑膜急性炎症期,苯甲青霉素和氨苄青霉素静脉或肌肉注射,脑脊液中能达到足够的抗菌浓度。但在流感杆菌感染时,用氨苄青霉素治疗,脑膜炎症消退后可能会复发,出乎意料之外的是加大剂量,或者改变疗法,仍能获得临床好转。对有用氯霉素指征者,问题最简单,因为氯霉素在脑脊液和血液的浓度比其他任何抗菌素为高。磺胺和甲氧苄氨嘧啶(TMP)亦易透过血脑屏障。增效新明磺已成功地用于治疗各种脑膜炎;另一方面,氨基糖甙类抗菌素如庆大霉素和托伯拉霉素(Tobramy-cin),静脉或肌肉注射后,脑脊液内不能达到足够的浓度,故需鞘内注射。
In the treatment of meningitis, depending on the route of antibiotic administration. Most of them are very easy to treat. In acute period of meningeal inflammation, injecting penicillin and ampicillin intravenously or intramuscularly can achieve sufficient antibacterial concentration in cerebrospinal fluid. However, in the case of influenza infection, with ampicillin treatment, meningitis may subside after the recurrence of the inflammation, unexpectedly, increase the dose, or change the treatment, still get a clinical turn for the better. The simplest thing to do for chloramphenicol indications is that chloramphenicol is higher in cerebrospinal fluid and blood than any other antibiotic. Sulfonamides and trimethoprim (TMP) also easily cross the blood-brain barrier. Synergism Neosamin has been successfully used in the treatment of various meningitis; on the other hand, aminoglycoside antibiotics such as gentamycin and tobramycin (Tobramy-cin), intravenous or intramuscular injection, cerebrospinal fluid Can not reach enough concentration, so need intrathecal injection.