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目的 探讨抑癌基因p21在喉鳞癌中表达及其与临床的关系。方法 采用免疫组化LSAB方法对37例喉原发性鳞癌、癌旁1.0cm组织及20例声带息肉组织行p21检测研究。结果 p21表达定位于胞浆,癌旁组织中有3例软骨细胞出现胞核阳性。喉癌组与癌旁组及声带息肉组之间表达率相比较,差异有显著性(P<0.05)。组织分化高者表达高。结论 p21在喉癌细胞的生长调控中起重要作用。
Objective To investigate the expression of tumor suppressor gene p21 in laryngeal squamous cell carcinoma and its clinical significance. Methods Immunohistochemical LSAB method 37 cases of primary squamous cell carcinoma of the larynx, adjacent tissue 1.0cm and 20 cases of vocal cord polyps p21 detection. Results The expression of p21 was localized in the cytoplasm. Three chondrocytes in paracancerous tissues showed positive nuclei. There were significant differences in the expression rates between laryngeal cancer group and adjacent non-cancerous tissues and vocal cord polyp group (P <0.05). High tissue expression of high expression. Conclusion p21 plays an important role in the regulation of laryngeal carcinoma cell growth.