【摘 要】
：
In order to maintain integrity of the genome, eukaryotic cells develop a complex DNA damage/ repair response network, which can induce cell cycle arrest, apopto
【机 构】
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Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya Medical School, Central South Un
论文部分内容阅读
In order to maintain integrity of the genome, eukaryotic cells develop a complex DNA damage/ repair response network, which can induce cell cycle arrest, apoptosis, or DNA repair. Chemo- and radiation therapies, which act primarily through the induction of DNA damage, are the most commonly used therapies for cancer. Impairment in the DNA damage response and repair system that protect cells from persistent DNA damage can affect the therapeutic efficacy of cancer. To date, accumulating evidence has suggested that long noncoding RNAs (IncRNAs) are involved in the regulation of the DNA damage/repair network. LncRNAs have been demonstrated to be master regulators of the genome at the transcriptional and post-transcriptional levels and play a key role in many physiological and pathological processes of cells. In this review, we will discuss the function of IncRNAs in regulating the cellular response to DNA damage.
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