肝内可见很多种色素颗粒,如脂褐素、Dubin-Johnson色素、含铁血黄素、铜和铜结合蛋白以及胆汁色素。在病理诊断过程中,准确判断色素的类型及出现部位对病理诊断至关重要。这些色素颗粒和沉着物在常规HE染色切片中多相似而不易区别,因此特殊染色的作用就在于确认和鉴别它们,从而判断其病理意义。本文主要介绍常见色素颗粒及相关特殊染色。 A variety of pigment particles are visible in the liver, such as lipofuscin, Dubin-Johnson pigments, hemosiderin, copper and copper-binding proteins, and bile pigments. In the pathological diagnosis process, accurately determine the type of pigment and the location of the pathological diagnosis is crucial. These pigment particles and sediments in the conventional HE-stained sections more similar and not easy to distinguish, so the role of special staining is to confirm and identify them to determine the pathological significance. This article describes the common pigment particles and related special staining.