目的:综述多潘立酮心脏不良反应国内外文献报道方法:检索中国知网全文数据库和medline数据库,以及加拿大和英国不良反应自愿报告数据库,获得多潘立酮引起的心脏不良反应的相关文献,分析不良反应的发生机制及影响因素。结果:多潘立酮可能引起QT间期延长、心脏骤停、室颤、房颤、室性早搏、心律失常、心动过速、尖端扭转、心肌梗死等心脏不良反应,与严重的心律失常和心源性猝死关系密切,老年人、男性、用药剂量、合并用药、患者病史是可能的影响因素。发生机制可能与其影响心室肌细胞膜上快速激活的延迟整流钾电流(IKr),使心肌复极时间及动作电位时间延长有关结论:应加强对多潘立酮心脏不良反应的监测,心脏传导间期延长、电解质紊乱、有充血性心衰等基础心脏病、老年男性等易感人群,以及合用影响心电活性药物时要慎重,生产企业应加强药品说明书的警示和技术培训 OBJECTIVE: To summarize the adverse drug reactions of domperidone in domestic and international literatures. Methods: Retrieve the CNKI full-text database and the medline database, as well as the database of voluntary adverse drug reactions in Canada and the United Kingdom, and obtain relevant literature on domperidone-induced adverse cardiac reactions, and analyze the mechanism of adverse reactions And influencing factors. RESULTS: Domperidone may cause cardiac adverse reactions such as QT prolongation, cardiac arrest, ventricular fibrillation, atrial fibrillation, ventricular premature beats, arrhythmia, tachycardia, torsades de pointes, myocardial infarction and so on, with serious arrhythmia and cardiogenic Sudden death is closely related to the elderly, males, medication dose, the combination of medication, the patient’s history is likely to influence the factors. The mechanism may be related to its rapid activation of delayed rectifier potassium current (IKr) on ventricular myocytes, and prolongation of myocardial repolarization time and action potential. CONCLUSION: Monitoring adverse reactions of domperidone heart, prolongation of cardiac conduction period, Disorders, congestive heart failure and other basic heart disease, elderly men and other susceptible populations, as well as co-affect the ECG active drugs should be cautious, manufacturers should strengthen the drug manual warnings and technical training