机体的免疫系统作为内在的抗肿瘤机构,能够启动免疫细胞通过介导先天免疫和获得性免疫清除肿瘤,而肿瘤细胞在与免疫细胞相互作用的过程中,也相应地会影响免疫系统的功能,引起免疫细胞功能下调或缺失,从而逃避免疫系统的攻击,造成免疫逃逸,例如：stat3广泛高表达于肿瘤细胞,且呈持续性激活状态,同时能产生大量的免疫抑制性细胞因子如VEGF和IL- The body’s immune system, as an intrinsic anti-tumor mechanism, activates immune cells to clear tumors by mediating innate and adaptive immunity. Tumor cells, in their interaction with immune cells, also affect the immune system’s function, Causing immune cell function down-regulation or deletion, thus evade the immune system attack and cause immune escape. For example, stat3 is widely expressed in tumor cells and is continuously activated, and at the same time can produce a large amount of immunosuppressive cytokines such as VEGF and IL -