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磷酸咯萘啶治疗抗氯喹恶性疟及间日疟均有疗效。动物实验表明,鼠疟P.berghei对咯萘啶很敏感。用相同剂量的咯萘啶或氯喹给感染P.cynomolgi的恒河猴作肌注或静脉滴注,咯萘啶使原虫转阴的时间比氯喹稍短,复燃时间则比氯喹稍长。本文报告用咯萘啶灌胃治疗经输血感染P.cynomolgi的恒河猴的实验结果。
Pyronaridine phosphate treatment of anti-chloroquine falciparum and vivax are effective. Animal experiments show that P. malacian P. berghei is sensitive to pyronaridine. In the same dose of pyronaridine or chloroquine, rhesus monkeys infected with P. cygnomgi were injected intramuscularly or intravenously. Pyronaridine dipped protozoa slightly shorter than chloroquine, and the rekindling time was slightly longer than that of chloroquine. This article reports the experimental results of pyronaridine gavage in the treatment of rhesus monkeys infected with P.cynomolgi by transfusion.