近日,从中科院生物化学与细胞生物学研究所获悉,最新一期国际权威学术期刊《细胞》发表了该所林安宁研究团队的最新成果,修改了为时15年的蛋白激酶IKK抑制肿瘤坏死因子TNF诱导细胞凋亡的理论,揭示了TNF不仅能调控细胞膜受体介导的凋亡通路,还能调控线粒体介导的凋亡通路,提出IKK抑制细胞凋亡的非经典模型。为炎症和炎症诱导的肿瘤等重大疾病的治疗提供了新思路、新方法。 Recently, the Institute of Biochemistry and Cell Biology from the Chinese Academy of Sciences was informed that the latest issue of the international authoritative academic journal “Cell” published the latest results of the Institute’s Lynn Anning research team to modify the 15-year protein kinase IKK inhibit tumor necrosis factor The theory of TNF-induced apoptosis reveals that TNF not only regulates the cell membrane-mediated apoptosis pathway, but also regulates the mitochondria-mediated apoptotic pathway, and proposes a non-canonical model of IKK inhibiting apoptosis. It provides new ideas and new methods for the treatment of major diseases such as inflammation and inflammation induced tumors.