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目的:探讨三阴性乳腺癌中整合素连接激酶(integrin-linked-kinase,ILK)的表达与患者预后的关系。方法:应用免疫组织化学SP法检测ILK在60例三阴性乳腺癌、36例非三阴性乳腺癌中的表达情况,并结合随访资料评价ILK表达水平对预测三阴性乳腺癌患者预后的价值。结果:三阴性乳腺癌中ILK的表达显著高于非三阴性乳腺癌(P<0.01);其ILK阳性表达与肿瘤大小、腋窝淋巴结转移、临床分期有关,而与患者年龄、月经状态无关;Kaplan-Meier生存曲线显示,ILK高表达组复发率高,病死率高,预后差。结论:ILK表达水平可作为判断三阴性乳腺癌患者预后的指标之一。
Objective: To investigate the relationship between the expression of integrin-linked-kinase (ILK) and prognosis in triple negative breast cancer. Methods: Immunohistochemical SP method was used to detect the expression of ILK in 60 cases of triple negative breast cancer and 36 cases of non-triple negative breast cancer. The value of ILK expression in predicting the prognosis of triple negative breast cancer patients was evaluated with follow-up data. Results: The expression of ILK in triple-negative breast cancer was significantly higher than that in non-triple negative breast cancer (P <0.01). The positive expression of ILK was related to tumor size, axillary lymph node metastasis and clinical stage, but not to patient’s age and menstrual status. Kaplan -Meier survival curves showed that the high expression of ILK high recurrence rate, high mortality, poor prognosis. Conclusion: ILK expression level can be used as a prognostic indicator of triple negative breast cancer patients.