Delphinium denudatum Wall. is one of the important medicinal herbs of traditional Persian medicine and is known as Jadwar. Medicinal plants are the most widely used drugs in traditional Persian medicine and has been used for various diseases since earlier times. The medicinal uses of Delphinium denudatum Wall. date back to over 1,000 years ago. Rhazes (845-925 C.E.) was the first Persian physician and scientist who reported the use of Delphinium denudatum Wall. as a herbal remedy. During the following centuries, the usages of Delphinium denudatum Wall. in the treatment of various diseases has been mentioned in the books and references of traditional Persian medicine for cures to various diseases such as neurologic and psychiatric disease, gastrointestinal disease, fever, pain, and poisoning. According to modern studies, the dried roots of Delphinium denudatum Wall. have antipyretic, antimicrobial, anticonvulsant, hepatoprotective, antioxidant, and pain-relieving properties. Biomolecules from roots of Delphinium denudatum Wall. were also identified as potential cures for central nervous system diseases as well as for the amelioration of morphine addiction. Delphinium denudatum Wall., with its properties involving the prevention of mitochondrial dysfunction, reduction of oxidative stress, and inflammation and immune dysregulation, can be utilized in curing inflammatory disorders. The effective therapeutic influence of root extract of Delphinium denudatum Wall. against several diseases needs to be confirmed through controlled clinical trials. This article reviews the different features of Delphinium denudatum Wall. and focuses on the well-known therapeutic effects of this herbal drug on various human disorders and animal disease models.