过氧化物体增殖活化受体γ(PPARγ)是核激素受体蛋白超家族成员。在配体作用下,PPARγ被激活,它通过连接到目标基因增强子序列上过氧化物酶增生因子反应元件(PPREs)而调节目标基因的转录活性。许多肺疾病存在肺纤维化的病理生理过程。PPARγ可能通过调节免疫反应,促进细胞凋亡和转化,调节细胞外基质沉积来调节炎症和增生反应。它对肺纤维化的调节作用日益受到重视。 Peroxisome proliferator-activated receptor γ (PPARγ) is a member of the nuclear hormone receptor protein superfamily. Under the action of a ligand, PPARγ is activated and it regulates the transcriptional activity of a target gene by ligating peroxisome proliferator reactive elements (PPREs) on the target gene enhancer sequence. Many lung diseases exist in the pathophysiology of pulmonary fibrosis. PPARγ may regulate inflammation and hyperplasia by regulating the immune response, promoting apoptosis and transforming cells and regulating extracellular matrix deposition. Its regulatory role in pulmonary fibrosis has received increasing attention.